Ethyl 2-({[4-(2-furoyl)-1-piperazinyl]acetyl}amino)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate(CAS: 835598-94-2)

Ethyl 2-({[4-(2-furoyl)-1-piperazinyl]acetyl}amino)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate is a crystalline compound with a molecular weight of approximately 531.35 g/mol. It has a moderate solubility in common organic solvents like DMSO and DMF. The compound is reactive, showing good stability under normal conditions but can react with strong bases. It is not volatile and does not sublimate easily.

Ethyl 2-({[4-(2-furoyl)-1-piperazinyl]acetyl}amino)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate is synthesized via a multi-step process involving the reaction of furoic acid and 1-piperazinecarboxylic acid. The key steps include acetylation, cyclization, and amidation. Commonly, this compound is prepared using catalytic amounts of acetic anhydride and a suitable base like triethylamine in an organic solvent. The overall yield is around 75-80%.

Ethyl 2-({[4-(2-furoyl)-1-piperazinyl]acetyl}amino)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate is primarily used in the pharmaceutical industry for developing new drugs due to its unique chemical structure. It also finds applications in the synthesis of organic semiconductors and in the development of advanced materials for sensors and polymers.

When handling Ethyl 2-({[4-(2-furoyl)-1-piperazinyl]acetyl}amino)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate, it is crucial to wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. Handle in a well-ventilated area or fume hood to avoid inhalation. Spills should be managed by carefully containing them and disposing of them according to local regulations. Always refer to the Safety Data Sheet (SDS) for comprehensive handling and safety information.