Compound Q&A
How is Ethyl 2-({[4-(2-furoyl)-1-piperazinyl]acetyl}amino)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate (CAS: 835598-94-2) typically synthesized?
Answer
![Ethyl 2-({[4-(2-furoyl)-1-piperazinyl]acetyl}amino)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate](https://static.chemtradehub.com/structs/835/835598-94-2-356d.webp "Ethyl 2-({[4-(2-furoyl)-1-piperazinyl]acetyl}amino)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate")
Ethyl 2-({[4-(2-furoyl)-1-piperazinyl]acetyl}amino)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate is synthesized via a multi-step process involving the reaction of furoic acid and 1-piperazinecarboxylic acid. The key steps include acetylation, cyclization, and amidation. Commonly, this compound is prepared using catalytic amounts of acetic anhydride and a suitable base like triethylamine in an organic solvent. The overall yield is around 75-80%.
About
CAS No
835598-94-2
English Name
Ethyl 2-({[4-(2-furoyl)-1-piperazinyl]acetyl}amino)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate
Molecular Formula
C21H25N3O5S
Molecular Weight
431.51 g/mol
SMILES
CCOC(=O)c1c2c(sc1NC(=O)CN3CCN(CC3)C(=O)c4ccco4)CCC2
InChIKey
KEVHLTCEMHIJTQ-UHFFFAOYSA-N
Last Updated: 2025-12-25 08:48
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