1-Bromo-3-fluoro-2-nitrobenzene(CAS: 886762-70-5)

1-Bromo-3-fluoro-2-nitrobenzene (CAS: 886762-70-5) is a crystalline compound with a molecular weight of approximately 237.03 g/mol. It is slightly soluble in water but soluble in organic solvents such as ethanol and acetone. Chemically, it is reactive towards nucleophiles, particularly bromide ions, and shows typical electrophilic aromatic substitution reactivity. It has a melting point of around 68-70°C and a boiling point of about 222-224°C under reduced pressure.

1-Bromo-3-fluoro-2-nitrobenzene (CAS: 886762-70-5) is synthesized by bromination of 3-fluoro-2-nitrobenzene with bromine in the presence of a phase transfer catalyst, such as tetra-n-butylammonium bromide. The reaction is typically conducted in a non-aqueous solvent like acetonitrile or N,N-dimethylformamide (DMF). The yield is usually high, and the product is isolated by recrystallization or distillation.

1-Bromo-3-fluoro-2-nitrobenzene (CAS: 886762-70-5) is used in the pharmaceutical industry for the synthesis of certain active pharmaceutical ingredients (APIs), particularly in the development of antiviral and anti-inflammatory drugs. It is also employed in the polymer industry for the preparation of specialty polymers with unique properties, and in the semiconductor industry for the fabrication of thin films and other electronic components.

When handling 1-Bromo-3-fluoro-2-nitrobenzene (CAS: 886762-70-5), appropriate personal protective equipment (PPE) is essential, including safety goggles, gloves, and lab coats. It should be handled in a fume hood to minimize exposure to vapors. Spills should be immediately cleaned up using appropriate absorbent materials and disposed of according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed information on handling and storage recommendations.