(+)-Blebbistatin(CAS: 1177356-70-5)

The physical and chemical properties of (+)-Blebbistatin include a white crystalline form, a molecular weight of approximately 341.3 g/mol, and good solubility in organic solvents like DMSO. It is less soluble in water. (+)-Blebbistatin is relatively stable under normal storage conditions but can be reactive with strong acids or bases. It is known for its ability to inhibit myosin light chain kinase, which makes it useful in research applications.

(+)-Blebbistatin is typically synthesized through a complex total synthesis involving multiple steps. The key steps include asymmetric synthesis using chiral pool chemistry and a series of purification steps. The overall yield is moderate, and the process requires careful control of reaction conditions to ensure high enantiomeric excess (ee).

(+)-Blebbistatin is primarily used in the pharmaceutical and research industries. It is a key tool in studying muscle contraction and cell motility. It is also used in polymer science for the investigation of molecular interactions and in the development of new materials. Additionally, it has applications in sensor technology and semiconductors for its ability to modulate cellular responses.

Handling (+)-Blebbistatin requires the use of personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a fume hood to minimize inhalation risks. Spills should be cleaned up immediately using appropriate materials and procedures. Always consult a safety data sheet (SDS) for detailed handling and safety information. Storage should be at room temperature away from direct sunlight and in a secure, labeled container.