3-Amino-5-chloropicolinonitrile(CAS: 408538-29-4)

3-Amino-5-chloropicolinonitrile is a white crystalline solid with a molecular weight of approximately 220.58 g/mol. It is soluble in water and organic solvents such as methanol and ethanol. This compound is moderately reactive, particularly with nucleophiles, and it is commonly used in organic synthesis due to its functional groups. It has a melting point around 195-200°C.

3-Amino-5-chloropicolinonitrile is typically synthesized via the reaction of 5-chloropicolinonitrile with an amine, such as aniline, in the presence of a base like potassium carbonate. The reaction proceeds via nucleophilic substitution, yielding a high yield of the target compound with good selectivity.

3-Amino-5-chloropicolinonitrile is primarily used in the pharmaceutical industry for the synthesis of various drug candidates. It is also utilized in the development of new materials, including polymers and sensors, due to its functional groups. Additionally, it has potential applications in the semiconductor industry for certain chemical processes.

When handling 3-Amino-5-chloropicolinonitrile, it is important to wear appropriate personal protective equipment (PPE), including safety goggles, gloves, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risk. Spills should be cleaned up using appropriate absorbents, and the area should be monitored for any leaks or spills. Always refer to the Safety Data Sheet (SDS) for detailed handling and storage information.