3-(1-Methyl-1H-pyrazol-5-yl)benzenesulfonyl chloride(CAS: 941716-85-4)

3-(1-Methyl-1H-pyrazol-5-yl)benzenesulfonyl chloride is a crystalline compound with a molecular weight of approximately 300.32 g/mol. It is poorly soluble in water but soluble in organic solvents like ethanol and dichloromethane. This compound is known for its high reactivity, particularly in nucleophilic substitution reactions. It is stable under normal conditions but should be stored in a cool, dry place to prevent degradation.

3-(1-Methyl-1H-pyrazol-5-yl)benzenesulfonyl chloride is typically synthesized via a two-step process. First, 5-chloropyrazole is reacted with benzene sulfonyl chloride to form the intermediate, followed by treatment with a base to form the final product. This synthesis usually requires the use of a catalyst and operates at room temperature with good yield and selectivity.

3-(1-Methyl-1H-pyrazol-5-yl)benzenesulfonyl chloride is primarily used in the pharmaceutical industry for the synthesis of various drug intermediates. It is also utilized in the polymer industry for the modification of polymers and in the electronics industry for semiconductor applications. Additionally, it finds use in the development of sensors due to its unique chemical properties.

When handling 3-(1-Methyl-1H-pyrazol-5-yl)benzenesulfonyl chloride, it is crucial to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Ensure that the compound is handled in a well-ventilated area or fume hood. Spills should be immediately neutralized with a suitable acid-base neutralizer and cleaned up with absorbent materials. Always refer to the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.