2,5-dihydrofuran-3-carboxylic acid(CAS: 1002728-73-5)

2,5-Dihydrofuran-3-carboxylic acid is a white crystalline solid with a molecular weight of approximately 124.1 g/mol. It has a pKa of about 4.7. This compound is slightly soluble in water but more soluble in organic solvents like ethanol and acetone. It is a weak acid and reacts easily with bases to form its sodium or potassium salts.

2,5-Dihydrofuran-3-carboxylic acid can be synthesized via the condensation of 2,5-dihydrofuran with acetic anhydride, followed by hydrolysis. Other methods include the reaction of 2,5-dihydrofuran with carboxylic acid chlorides or anhydrides, yielding a higher yield and selectivity. These reactions are commonly catalyzed by acid or base promoters.

2,5-Dihydrofuran-3-carboxylic acid is primarily used in the pharmaceutical and polymer industries. It serves as a precursor for the synthesis of various drugs and is also utilized in the production of polymeric materials. Additionally, it finds applications in the sensing and semiconductor industries due to its chemical reactivity.

When handling 2,5-dihydrofuran-3-carboxylic acid, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. This compound should be handled in a well-ventilated area or under a fume hood to minimize exposure to air. Spills should be cleaned up using appropriate absorbent materials, and proper waste disposal procedures should be followed. Always consult the Safety Data Sheet (SDS) for detailed safety information.