2-Bromo-4-[4-(trifluoromethyl)phenyl]-1,3-thiazole(CAS: 886367-52-8)

2-Bromo-4-[4-(trifluoromethyl)phenyl]-1,3-thiazole is a crystalline solid with a molecular weight of approximately 351.04 g/mol. It has a low water solubility, approximately 0.02 g/L at 25°C. The compound exhibits good thermal stability but is reactive towards nucleophiles. It is insoluble in water but soluble in organic solvents like dichloromethane and acetone.

2-Bromo-4-[4-(trifluoromethyl)phenyl]-1,3-thiazole is typically synthesized via a nucleophilic substitution reaction. The synthesis involves the reaction of 4-bromo-1,3-thiazole with 4-bromotoluene in the presence of a base such as potassium tert-butoxide. The reaction is conducted in an aprotic solvent like tetrahydrofuran (THF) at room temperature, followed by treatment with a trifluoromethylating agent like trifluoromethyl sulfonic anhydride (CF3SO2O2) in an appropriate solvent.

2-Bromo-4-[4-(trifluoromethyl)phenyl]-1,3-thiazole finds applications in the pharmaceutical industry for the synthesis of various medicinal compounds. It is also used in the development of sensors and semiconductors, particularly in the fabrication of organic light-emitting diodes (OLEDs) and other electronic devices due to its specific chemical properties.

When handling 2-Bromo-4-[4-(trifluoromethyl)phenyl]-1,3-thiazole, it is essential to use personal protective equipment (PPE) such as gloves, goggles, and lab coat. The compound should be stored in a cool, dry place away from heat and sources of ignition. In case of a spill, the area should be ventilated, and the spill should be cleaned up using appropriate methods as outlined in the Safety Data Sheet (SDS).