Compound Q&A
How is 2-Bromo-4-[4-(trifluoromethyl)phenyl]-1,3-thiazole (CAS: 886367-52-8) typically synthesized?
Answer
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2-Bromo-4-[4-(trifluoromethyl)phenyl]-1,3-thiazole is typically synthesized via a nucleophilic substitution reaction. The synthesis involves the reaction of 4-bromo-1,3-thiazole with 4-bromotoluene in the presence of a base such as potassium tert-butoxide. The reaction is conducted in an aprotic solvent like tetrahydrofuran (THF) at room temperature, followed by treatment with a trifluoromethylating agent like trifluoromethyl sulfonic anhydride (CF3SO2O2) in an appropriate solvent.
About
CAS No
886367-52-8
English Name
2-Bromo-4-[4-(trifluoromethyl)phenyl]-1,3-thiazole
Molecular Formula
C10H5BrF3NS
Molecular Weight
308.12 g/mol
SMILES
C1=CC(=CC=C1C2=CSC(=N2)Br)C(F)(F)F
InChIKey
NQYLAXLAADNHAO-UHFFFAOYSA-N
Last Updated: 2026-01-13 15:28
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