4-Bromo-6-methylpyrimidine(CAS: 69543-98-2)

4-Bromo-6-methylpyrimidine is a white crystalline solid with a molecular weight of 216.03 g/mol. It has a melting point of 112-114°C and a limited solubility in water. The compound is relatively stable but can react with strong acids or bases. It is generally insoluble in water but soluble in organic solvents like methanol, ethanol, and dimethylformamide.

4-Bromo-6-methylpyrimidine is typically synthesized by bromination of 6-methylpyrimidine using N-bromosuccinimide (NBS) in the presence of a suitable catalyst like benzoyl peroxide under anhydrous conditions. The reaction yields a high percentage of the desired product with good selectivity. The process involves careful monitoring to ensure the desired bromination occurs at the correct position.

4-Bromo-6-methylpyrimidine is used in various industries, including pharmaceuticals, where it serves as a precursor for the synthesis of antitumor and antiviral drugs. It is also utilized in the production of certain dyes, as a reagent in organic synthesis, and in the development of sensors and other materials for electronic applications.

When handling 4-Bromo-6-methylpyrimidine, it is essential to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Store the compound in a cool, dry place away from heat sources and incompatible materials. Use a fume hood during preparation to minimize inhalation of fumes. In case of a spill, clean up with caution using absorbent materials and dispose of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and emergency procedures.