7-Amino-4-(trifluoromethyl)-2(1H)-quinolinone(CAS: 58721-76-9)

7-Amino-4-(trifluoromethyl)-2(1H)-quinolinone (CAS: 58721-76-9) is a crystalline solid with a molecular weight of approximately 289.1 g/mol. It has a melting point of around 220°C and poor water solubility. It is moderately reactive, showing limited reactivity with common organic solvents and bases. It is typically stable under normal storage conditions but should be protected from moisture and strong acids.

7-Amino-4-(trifluoromethyl)-2(1H)-quinolinone is synthesized via the condensation of 4-chloroquinoline-2(1H)-one with trifluoroacetic anhydride. The reaction is carried out in a mixture of acetic acid and trifluoroacetic anhydride, with a yield of about 70-80%. The reaction is catalyzed by a suitable acid and is typically conducted under mild conditions.

7-Amino-4-(trifluoromethyl)-2(1H)-quinolinone (CAS: 58721-76-9) is primarily used in pharmaceuticals for the synthesis of various bioactive compounds. It is also utilized in chemical synthesis as a building block for organic compounds and in the development of sensors and semiconductors due to its electronic properties.

When handling 7-Amino-4-(trifluoromethyl)-2(1H)-quinolinone (CAS: 58721-76-9), ensure the use of appropriate personal protective equipment (PPE) such as gloves, goggles, and lab coat. Work in a well-ventilated area or exhaust hood to minimize inhalation. Spills should be contained and disposed of according to local hazardous waste regulations. Always consult the Material Safety Data Sheet (MSDS) for detailed handling and safety instructions.