Aliskiren hemifumarate(CAS: 173334-58-2)

Aliskiren hemifumarate (CAS: 173334-58-2) is a crystalline solid with a molecular weight of approximately 625.6 g/mol. It has a solubility of about 200 mg/mL in water and is practically insoluble in common organic solvents like ethanol and chloroform. Chemically, it is stable at room temperature but can degrade under strongly acidic or basic conditions. It shows minimal reactivity towards common chemicals and is best stored in a dry, cool place away from direct sunlight.

Aliskiren hemifumarate (CAS: 173334-58-2) is synthesized via a multi-step process involving the condensation of aliskiren with fumaric acid hemifumarate. The reaction typically uses acetic anhydride as a condensing agent and occurs under moderate temperature and pressure conditions. The yield is around 90%, and the method is known for its high selectivity and good purity.

Aliskiren hemifumarate (CAS: 173334-58-2) is primarily used in the pharmaceutical industry. It is an active pharmaceutical ingredient (API) used in the treatment of hypertension. While it has potential applications in other industries, its main use is in drug development and production.

When handling Aliskiren hemifumarate (CAS: 173334-58-2), it is important to wear appropriate personal protective equipment (PPE), including gloves and safety goggles. Store it in a well-ventilated area and avoid contact with acids or bases. In case of a spill, neutralize with a buffer solution and dispose of according to local regulations. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information.