6-Bromo[1,3]oxazolo[5,4-b]pyridine(CAS: 886372-90-3)

6-Bromo[1,3]oxazolo[5,4-b]pyridine is a crystalline solid with a molecular weight of approximately 254.04 g/mol. It has a low solubility in water but is more soluble in organic solvents like dichloromethane and ethanol. Chemically, it is moderately reactive, particularly towards nucleophiles, and can undergo substitution reactions. It has a melting point around 150-155°C.

6-Bromo[1,3]oxazolo[5,4-b]pyridine can be synthesized using a multi-step process involving the reaction of bromine with 1,3-oxazolo[5,4-b]pyridine. The synthesis typically utilizes a mild oxidant and involves careful control of reaction conditions to achieve high selectivity and yield. Common solvents include dichloromethane and acetic acid.

6-Bromo[1,3]oxazolo[5,4-b]pyridine is used in various industries, particularly in pharmaceuticals where it is used as an intermediate for drug synthesis. Its application in polymers, sensors, and semiconductors is also being explored due to its unique chemical properties.

When handling 6-Bromo[1,3]oxazolo[5,4-b]pyridine, it is essential to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated fume hood to minimize exposure. Spills should be handled carefully, and spill kits should be readily available. Always refer to the Safety Data Sheet (SDS) for detailed safety information.