1-[4-(Trifluoromethyl)phenyl]cyclopropanecarbonitrile(CAS: 124276-61-5)

1-[4-(Trifluoromethyl)phenyl]cyclopropanecarbonitrile is a colorless to white crystalline solid with a molecular weight of approximately 262.13 g/mol. It has low solubility in water but is soluble in common organic solvents like methanol and dichloromethane. The compound is known for its chemical stability and low reactivity under normal conditions, although it may undergo hydrolysis in the presence of moisture.

1-[4-(Trifluoromethyl)phenyl]cyclopropanecarbonitrile is usually synthesized via a multistep process starting from 4-(trifluoromethyl)benzoyl chloride and cyclopropanecarbaldehyde. The synthesis involves nucleophilic addition followed by hydrolysis and nitrile formation, requiring careful control of reaction conditions to achieve high yield and selectivity.

1-[4-(Trifluoromethyl)phenyl]cyclopropanecarbonitrile is utilized in various industries, particularly in pharmaceuticals for medicinal chemistry and drug synthesis due to its unique chemical structure. It also finds applications in the polymer industry for synthesizing advanced polymers and in the electronics sector for producing semiconductor materials.

When handling 1-[4-(Trifluoromethyl)phenyl]cyclopropanecarbonitrile, it is essential to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Ensure the work is conducted in a well-ventilated area or a fume hood to minimize inhalation of vapors. Spills should be cleaned up using absorbent materials and followed by thorough washing with water. Always refer to the Safety Data Sheet (SDS) for detailed emergency procedures and storage guidelines.