2-Chloro-5-methoxynicotinic acid(CAS: 74650-71-8)

2-Chloro-5-methoxynicotinic acid is a crystalline solid with a molecular weight of approximately 192.59 g/mol. It is slightly soluble in water and more soluble in organic solvents. This compound is known for its strong acidity and can undergo reactions such as esterification and nucleophilic substitution.

2-Chloro-5-methoxynicotinic acid is commonly synthesized through the chlorination of 5-methoxynicotinic acid. This process typically involves the use of thionyl chloride as a chlorinating agent, followed by purification through recrystallization from a suitable solvent.

2-Chloro-5-methoxynicotinic acid is primarily used in the pharmaceutical industry as an intermediate in the synthesis of certain drugs. It is also used in the production of some agricultural chemicals and in the development of sensors.

When handling 2-Chloro-5-methoxynicotinic acid, it is important to use appropriate personal protective equipment (PPE) such as gloves and safety goggles. Work should be conducted in a fume hood due to its potentially harmful vapors. Proper spill handling procedures should be followed, and the Safety Data Sheet (SDS) should be consulted for detailed safety information.