Methyl 3-(5-hydroxy-2-pyrimidinyl)benzoate(CAS: 1092568-87-0)

Methyl 3-(5-hydroxy-2-pyrimidinyl)benzoate (CAS: 1092568-87-0) is a crystalline compound with a molecular weight of approximately 268.24 g/mol. It has a pKa value of around 5.5 and is slightly soluble in water. This compound is known for its reactivity in nucleophilic substitution reactions and is used in various synthetic procedures. Its solubility in common organic solvents such as ethanol and acetone is moderate to good.

Methyl 3-(5-hydroxy-2-pyrimidinyl)benzoate (CAS: 1092568-87-0) is typically synthesized by the condensation of 5-hydroxy-2-pyrimidinone with methyl benzoate in the presence of a catalyst such as p-toluenesulfonic acid (PTSA). The reaction yields a mixture that can be purified by recrystallization. The yield is generally around 70-80%, and the method is selective for the desired product.

Methyl 3-(5-hydroxy-2-pyrimidinyl)benzoate (CAS: 1092568-87-0) is used in the pharmaceutical industry for the synthesis of certain drugs, particularly those involving pyrimidine derivatives. It is also used in the polymer industry as a monomer and in the development of sensors due to its specific chemical properties.

Handling Methyl 3-(5-hydroxy-2-pyrimidinyl)benzoate (CAS: 1092568-87-0) requires the use of personal protective equipment (PPE) such as gloves, goggles, and a laboratory coat. The compound should be handled in a well-ventilated area or a fume hood. Spills should be cleaned up using appropriate absorbent materials, and the area should be flushed with water. Always consult the Safety Data Sheet (SDS) for detailed information and procedures.