2-(1-Hydroxycyclohexyl)-2-(4-methoxyphenyl)acetonitrile(CAS: 131801-69-9)

2-(1-Hydroxycyclohexyl)-2-(4-methoxyphenyl)acetonitrile is a colorless to light yellow liquid with a molecular weight of approximately 280.33 g/mol. It has a solubility of up to 1.3 g/100 mL in water. This compound is known for its low reactivity under normal conditions, but it can undergo hydrolysis in the presence of water or acid. It is insoluble in water but soluble in organic solvents such as ethanol and acetone.

2-(1-Hydroxycyclohexyl)-2-(4-methoxyphenyl)acetonitrile is typically synthesized via a multistep process involving the reaction of 4-methoxybenzaldehyde with cyclohexanol, followed by acetonitrile addition. This reaction often uses a Lewis acid catalyst such as aluminum chloride to promote the aldol condensation and subsequent acetonitrile addition. The yield and selectivity of the reaction can be enhanced by optimizing reaction conditions, including temperature and solvent choice.

2-(1-Hydroxycyclohexyl)-2-(4-methoxyphenyl)acetonitrile is used in various industries, including pharmaceuticals, where it serves as an intermediate in the synthesis of certain drugs. It is also utilized in the production of polymers, where its unique structure can enhance the properties of the resulting materials. Additionally, it finds applications in the development of sensors and semiconductors due to its chemical stability and functional groups.

When handling 2-(1-Hydroxycyclohexyl)-2-(4-methoxyphenyl)acetonitrile, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, safety glasses, and a lab coat. It should be stored in a fume hood and away from heat sources. In case of a spill, the area should be ventilated, and the spill should be cleaned up carefully using appropriate materials. The material safety data sheet (MSDS) or safety data sheet (SDS) should be consulted for detailed handling and disposal instructions.