Ethyl 2,6-dichloro-5-fluoronicotinate(CAS: 82671-03-2)

Ethyl 2,6-dichloro-5-fluoronicotinate (CAS: 82671-03-2) is a crystalline solid with a molecular weight of approximately 318.03 g/mol. It has limited water solubility and is soluble in common organic solvents like ethanol and acetone. The compound exhibits moderate reactivity towards nucleophiles and can be used in various synthetic transformations. It is stable under normal storage conditions but should be handled with care due to its potential for hydrolysis under basic conditions.

Ethyl 2,6-dichloro-5-fluoronicotinate can be synthesized through a multi-step process involving the first chlorination of nicotinic acid, followed by the selective alkylation with ethylmagnesium bromide. This method provides good yield and selectivity. Catalysts such as aluminum chloride are often used to enhance reactivity and control the reaction pathway.

Ethyl 2,6-dichloro-5-fluoronicotinate (CAS: 82671-03-2) is primarily used in the pharmaceutical industry for the synthesis of certain intermediates and active pharmaceutical ingredients. It is also explored in the polymer industry for the development of novel materials and in sensor technology for specific chemical detection applications.

When handling Ethyl 2,6-dichloro-5-fluoronicotinate (CAS: 82671-03-2), it is essential to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure to vapors. Spills should be managed using appropriate absorbents and disposed of according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed guidelines on handling and storage.