Compound Q&A
How is Ethyl 2,6-dichloro-5-fluoronicotinate (CAS: 82671-03-2) typically synthesized?
Answer
Ethyl 2,6-dichloro-5-fluoronicotinate can be synthesized through a multi-step process involving the first chlorination of nicotinic acid, followed by the selective alkylation with ethylmagnesium bromide. This method provides good yield and selectivity. Catalysts such as aluminum chloride are often used to enhance reactivity and control the reaction pathway.
About
CAS No
82671-03-2
English Name
Ethyl 2,6-dichloro-5-fluoronicotinate
Molecular Formula
C8H6Cl2FNO2
Molecular Weight
238.05 g/mol
SMILES
CCOC(=O)C1=CC(F)=C(Cl)N=C1Cl
InChIKey
FPPLCOWQBGOFDU-UHFFFAOYSA-N
Last Updated: 2025-12-26 02:37
