2-{2-[2-(2-Azidoethoxy)ethoxy]ethoxy}-1-[(4-methylphenyl)sulfonyl]ethanol(CAS: 168640-82-2)

2-{2-[2-(2-Azidoethoxy)ethoxy]ethoxy}-1-[(4-methylphenyl)sulfonyl]ethanol is a colorless to slightly yellowish crystalline solid with a molecular weight of approximately 534.55 g/mol. It is poorly soluble in water but soluble in common organic solvents such as ethanol, methanol, and dimethyl sulfoxide. Chemically, it is highly reactive due to the azido group, making it susceptible to reduction and decomposition. It has a high melting point and is stable under normal conditions but requires careful handling due to its reactivity.

2-{2-[2-(2-Azidoethoxy)ethoxy]ethoxy}-1-[(4-methylphenyl)sulfonyl]ethanol is typically synthesized using a multi-step process involving the protection of the hydroxyl groups, followed by the introduction of the azido group, and then the coupling with the sulfonyl chloride. This synthesis often requires the use of protecting agents and careful control of reaction conditions to achieve high yield and selectivity. Common catalysts include Lewis acids and base-mediated reactions.

2-{2-[2-(2-Azidoethoxy)ethoxy]ethoxy}-1-[(4-methylphenyl)sulfonyl]ethanol is primarily used in pharmaceuticals for its azido functionality, which can be used in drug synthesis and as a building block for more complex molecules. It is also used in the polymer industry for unique chemical modification of polymers, and in the semiconductor industry for its use in photoresists and other advanced materials. Additionally, it finds applications in sensing technologies due to its reactivity.

When handling 2-{2-[2-(2-Azidoethoxy)ethoxy]ethoxy}-1-[(4-methylphenyl)sulfonyl]ethanol, it is crucial to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Ensure the use of a fume hood to minimize inhalation risks. Spills should be cleaned up with care, using absorbent materials, and the area should be well-ventilated. Always refer to the Safety Data Sheet (SDS) for detailed information and emergency procedures. Storage should be in a cool, dry place, away from heat and direct sunlight.