[2-Fluoro-6-(trifluoromethyl)phenyl]boronic acid(CAS: 313545-34-5)

(2-Fluoro-6-(trifluoromethyl)phenyl)boronic acid (CAS: 313545-34-5) is a crystalline solid with a molecular weight of approximately 342.11 g/mol. It has a low solubility in water but is more soluble in organic solvents like ethanol and acetone. This compound is known for its high reactivity, particularly in Suzuki coupling reactions, and is often used as a boronic acid derivative in organic synthesis.

(2-Fluoro-6-(trifluoromethyl)phenyl)boronic acid (CAS: 313545-34-5) can be synthesized through a two-step process starting with the bromination of 2-fluoro-6-(trifluoromethyl)benzene followed by the subsequent nucleophilic substitution with sodium borohydride. Commonly, this process involves the use of sodium borohydride as a mild reducing agent, yielding a high yield and good selectivity.

(2-Fluoro-6-(trifluoromethyl)phenyl)boronic acid (CAS: 313545-34-5) is widely used in the pharmaceutical industry for the synthesis of drug intermediates due to its reactivity in coupling reactions. It also finds applications in the polymer industry for the modification of polymers, in sensor technology for detection of specific analytes, and in semiconductor manufacturing for material preparation.

When handling (2-Fluoro-6-(trifluoromethyl)phenyl)boronic acid (CAS: 313545-34-5), it is essential to use appropriate personal protective equipment, including gloves, safety goggles, and a lab coat. Work must be performed in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up with care, and the material safety data sheet (MSDS) should be consulted for specific spill procedures. Ensure proper storage in a secure, cool, and dry location away from flammable materials.