(3R)-Tetrahydro-3-furanamine 4-methylbenzenesulfonate (1:1)(CAS: 111769-27-8)

(3R)-Tetrahydro-3-furanamine 4-methylbenzenesulfonate (CAS: 111769-27-8) is a solid compound with a crystalline form. It has a molecular weight of approximately 254.26 g/mol and a solubility in water of 0.001 g/L at 25°C. The compound is moderately reactive, showing basic properties due to the amine group. It is insoluble in nonpolar solvents but soluble in polar solvents like methanol and dimethylformamide.

(3R)-Tetrahydro-3-furanamine 4-methylbenzenesulfonate is typically synthesized by reacting 4-methylbenzenesulfonyl chloride with (3R)-tetrahydro-3-furanamine in the presence of a base such as triethylamine. The reaction proceeds via nucleophilic substitution, yielding the desired sulfonate ester with good selectivity and moderate yield. Optimal conditions for the synthesis include a temperature range of 0-5°C.

(3R)-Tetrahydro-3-furanamine 4-methylbenzenesulfonate (CAS: 111769-27-8) is used in the pharmaceutical industry for its potential as a precursor in the synthesis of various bioactive compounds. It also finds applications in the development of sensors and semiconductors due to its chemical properties. In polymer science, it can be used in the modification of polymers to improve their functionality.

When handling (3R)-Tetrahydro-3-furanamine 4-methylbenzenesulfonate (CAS: 111769-27-8), it is essential to use personal protective equipment such as gloves, goggles, and a lab coat. Ensure the use of a fume hood during handling to avoid inhalation. Spills should be cleaned up using appropriate absorbent materials followed by rinsing the area with water. Always consult the Material Safety Data Sheet (MSDS) for detailed handling and safety information.