Compound Q&A
How is (3R)-Tetrahydro-3-furanamine 4-methylbenzenesulfonate (CAS: 111769-27-8) typically synthesized?
Answer
(3R)-Tetrahydro-3-furanamine 4-methylbenzenesulfonate is typically synthesized by reacting 4-methylbenzenesulfonyl chloride with (3R)-tetrahydro-3-furanamine in the presence of a base such as triethylamine. The reaction proceeds via nucleophilic substitution, yielding the desired sulfonate ester with good selectivity and moderate yield. Optimal conditions for the synthesis include a temperature range of 0-5°C.
About
CAS No
111769-27-8
English Name
(3R)-Tetrahydro-3-furanamine 4-methylbenzenesulfonate (1:1)
Molecular Formula
C11H17NO4S
Molecular Weight
259.33 g/mol
SMILES
CC1=CC=C(C=C1)S(=O)(=O)O.C1COCC1N
InChIKey
BZXPLADBSZWDIH-FZSMXKCYSA-N
Last Updated: 2025-10-20 00:35
