5-Fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide(CAS: 1350653-27-8)

5-Fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide is a crystalline solid with a molecular weight of approximately 331.2 g/mol. It has a low solubility in water but is more soluble in organic solvents such as methanol and acetonitrile. This compound is relatively stable under normal conditions but reacts readily with strong bases. It is often used in medicinal chemistry due to its pharmacological activity.

5-Fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide can be synthesized through a multi-step process involving alkylation and nucleophilic aromatic substitution reactions. Typically, this involves the reaction of 2-fluorobenzyl bromide with a 5-fluoropyrazolo[3,4-b]pyridine derivative. The synthesis usually requires the use of a phase-transfer catalyst and occurs with high selectivity, yielding a product with a purity of over 95%.

5-Fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide is primarily used in the pharmaceutical industry for its therapeutic potential, particularly in treating certain types of cancer. It is also explored for use in sensor technology due to its specific interactions with certain biological molecules.

When handling 5-Fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide, it is essential to use appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. This compound should be stored in a cool, dry place away from direct sunlight. In the event of a spill, the area should be ventilated, and the spill should be handled according to the Material Safety Data Sheet (MSDS) guidelines. The compound should always be handled under a fume hood to minimize exposure.