4-Methyl-1,2-oxazole-3-carboxylic acid(CAS: 215872-46-1)

4-Methyl-1,2-oxazole-3-carboxylic acid is a white crystalline solid with a molecular weight of 145.17 g/mol. It has a solubility of about 1.5 g/L in water. Chemically, it is reactive, particularly towards nucleophiles. It is slightly soluble in common organic solvents like ethanol and methanol.

4-Methyl-1,2-oxazole-3-carboxylic acid can be synthesized via the condensation of methyl acetoacetate with formaldehyde and subsequent acidification. This reaction is typically catalyzed by an acid, such as sulfuric acid, and proceeds with good selectivity and moderate to high yield.

4-Methyl-1,2-oxazole-3-carboxylic acid is used in the pharmaceutical industry for the synthesis of certain drugs, and in the chemical industry as a precursor for various organic compounds. It also finds applications in the production of polymers and as a reagent in analytical chemistry and sensor technology.

When handling 4-Methyl-1,2-oxazole-3-carboxylic acid, it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. Spills should be cleaned up according to standard procedures, and the safety data sheet (SDS) should be consulted for detailed instructions.