5-fluoro-3-nitro-pyridin-2-amine(CAS: 212268-12-7)

5-Fluoro-3-nitro-pyridin-2-amine is a crystalline solid with a molecular weight of approximately 196.07 g/mol. It has a solubility of about 53 mg/L in water at 25°C. The compound is known for its high reactivity, particularly with reducing agents. It is slightly soluble in ethanol and almost insoluble in most organic solvents.

5-Fluoro-3-nitro-pyridin-2-amine is typically synthesized via the amination of 5-fluoro-3-nitropyridine with ammonia or an amine. The reaction is usually carried out in an aqueous medium with a catalyst such as sodium hydroxide. The yield is generally around 75-85%, with good selectivity towards the target amine.

5-Fluoro-3-nitro-pyridin-2-amine is used in the pharmaceutical industry for the synthesis of certain drugs. It can also be applied in the sensing technology for detecting specific chemical species. Its potential applications in semiconductors and polymers are also being explored due to its unique electronic properties.

When handling 5-fluoro-3-nitro-pyridin-2-amine, it is essential to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a fume hood to minimize exposure. Spills should be handled by neutralizing with an appropriate reagent before cleaning up. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information and emergency procedures.