N-Succinimidyl 4-(p-Maleimidophenyl)butyrate(CAS: 79886-55-8)

N-Succinimidyl 4-(p-Maleimidophenyl)butyrate (CAS: 79886-55-8) is a white to off-white crystalline solid with a molecular weight of approximately 314.3 g/mol. It is sparingly soluble in water but soluble in organic solvents like DMF and DMSO. The compound is highly reactive towards amine functionalities, making it useful for conjugation reactions. It features both succinimidyl and maleimide groups, which enhance its reactivity and specificity in bioconjugation applications.

N-Succinimidyl 4-(p-Maleimidophenyl)butyrate (CAS: 79886-55-8) is typically synthesized by the condensation of succinimidyl butyrate with 4-maleimidophenyl boronic acid in the presence of a base like triethylamine. The reaction yields the desired product with good selectivity and yield. The process involves careful monitoring of pH and temperature to optimize the reaction conditions.

N-Succinimidyl 4-(p-Maleimidophenyl)butyrate (CAS: 79886-55-8) is widely used in various industries including pharmaceuticals for drug conjugation, biotechnology for protein labeling, polymer science for modifying surfaces, and sensor technology for developing bioactive sensors. It is also utilized in semiconductor manufacturing for functionalizing substrates. Its ability to form stable covalent bonds with amines makes it a valuable reagent in these applications.

When handling N-Succinimidyl 4-(p-Maleimidophenyl)butyrate (CAS: 79886-55-8), it is important to wear appropriate personal protective equipment (PPE) including gloves, safety goggles, and a lab coat. The compound should be used in a well-ventilated area or under a fume hood due to its reactive nature. Spills should be cleaned up promptly using appropriate absorbent materials. Always consult the Material Safety Data Sheet (MSDS) or safety data sheet (SDS) for specific handling and disposal instructions. Handling this compound should be done with caution to prevent skin and eye irritation.