Methyl 5-deoxy-2,3-O-isopropylidene-D-ribofuranoside(CAS: 78341-97-6)

Methyl 5-deoxy-2,3-O-isopropylidene-D-ribofuranoside is a colorless crystalline solid with a high melting point. Its molecular weight is approximately 292.27 g/mol. It has low solubility in water but good solubility in organic solvents. This compound exhibits moderate reactivity, particularly towards nucleophilic substitution reactions.

Methyl 5-deoxy-2,3-O-isopropylidene-D-ribofuranoside is synthesized via a multistep synthetic route involving protective group chemistry. Commonly, this involves the protection of the ribose hydroxyl groups, followed by methylation and isopropylidene protection. The overall yield is around 75%, and the process typically requires the use of solid-phase techniques and mild acid catalysts.

Methyl 5-deoxy-2,3-O-isopropylidene-D-ribofuranoside is primarily used in the pharmaceutical industry as an intermediate in the synthesis of nucleosides and nucleotides. It is also of interest in the chemical and polymer industries for its potential as a monomer in the development of new materials.

When handling Methyl 5-deoxy-2,3-O-isopropylidene-D-ribofuranoside, it is essential to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a fume hood to minimize inhalation risks. Spills should be cleaned up using appropriate absorbents, and proper disposal methods should be followed. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information.