Staurosporine(CAS: 62996-74-1)

Staurosporine is a natural product alkaloid with the chemical formula C17H18N4O6. It is a potent inhibitor of protein kinases, known for its ability to block multiple kinase activities, making it a valuable compound in biochemical research. Staurosporine appears as a white solid and is highly soluble in dimethyl sulfoxide (DMSO). Its structure includes a complex tetracyclic ring system and nitrogen-containing functionalities, contributing to its biological activity.

Staurosporine is primarily used in pharmaceutical research as a kinase inhibitor, aiding in the study of cell signaling pathways and apoptosis. It serves as a tool for drug development and is also employed in biochemical assays to investigate enzyme inhibition mechanisms. Due to its broad-spectrum activity, Staurosporine is utilized in cancer research and as a model compound for understanding kinase-dependent processes in cellular biology.

Staurosporine is toxic and requires careful handling. It can cause harm if inhaled, ingested, or absorbed through the skin, so protective measures such as gloves, goggles, and proper ventilation are essential. Safety standards emphasize adherence to OSHA guidelines and the use of personal protective equipment (PPE). Always consult safety data sheets (SDS) for detailed handling protocols and exposure limits.

Staurosporine should be stored in a sealed, airtight container in a cool (2-8°C), dry, and dark location to maintain stability. It is sensitive to moisture and light, which can degrade its potency. Avoid exposure to humidity and ensure storage conditions prevent contamination. Keep away from incompatible substances and store in a well-ventilated area as per safety recommendations.