Staurosporine | CAS No. 62996-74-1

Staurosporine

Basic Information

View in Editor

CAS Number

62996-74-1

Molecular Formula

C28H26N4O3

Molecular Weight

466.5 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

270°C

Boiling Point

677.5±55.0 °C at 760 mmHg

Density

1.5600

Water Solubility

Soluble in DMSO or ethanol.Soluble in dimethyl sulfoxide , dimethyl formamide, ethyl acetate, hot acetone and ethanol. Slightly soluble in chloroform and methanol. Insoluble in water.

Flash Point

363.6±31.5 °C

Solubility

DMSO: soluble

Specific Rotation

D25 +35.0° (c = 1 in methanol); D22 +56.1° (c = 0.14 in methanol)

SMILES

View in Editor

CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)NC)OC

InChI

InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1

InChIKey

HKSZLNNOFSGOKW-FYTWVXJKSA-N

LogP

4.354000000000004

Topological Polar Surface Area

69.45 Å²

Hydrogen Bond Donor/Acceptor

2 / 7

Complexity

901

Safety Information

View Safety Information

GHS Hazard Pictograms

H340

H350

Hazard Statement

H340 May cause genetic defects
Germ cell mutagenicity

H350 May cause cancer
Carcinogenicity

Hazard Class

Class 3 Class 3

Synonyms & References

English

1sm2
STAUROSPORINE [MI]
NCGC00162400-05
(5S,6R,7R,9R)-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9,15,16-hexahydro-5H,14H-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-14-one
1xjd
BRD-K17953061-001-08-5
NS00011817
Staurosporine, 8
DB02010
MEGxm0_000307
1nvr
9,13-Epoxy-1H,9H-diindolo(1,2,3-gh:3',2',1'-lm)pyrrolo(3,4-j)(1,7)-benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-11-(methylamino)-, (9S-(9alpha,10beta,11beta,13alpha)-
1yhs
HY-15141
Staurosporine & TNF
1stc
GTPL346
BRD-K17953061-001-05-1
9,13-Epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-11-(methylamino)-, [9S-(9alpha,10beta,11beta,13alpha)]-
BDBM2579
AM2282
CGP 39360
Staurosporine & Tumor necrosis factor (TNF)
AM 2282
(2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-16-one
SCHEMBL8157
Antibiotic 230
BRD-K17953061-001-04-4
Antibiotic AM-2282
NCGC00162400-03
BRD-K17953061-001-11-9

MDL Number

MFCD18252446

Customs Code

29419090

FAQ

What is Staurosporine (CAS: 62996-74-1)?

Staurosporine is a natural product alkaloid with the chemical formula C17H18N4O6. It is a potent inhibitor of protein kinases, known for its ability to block multiple kinase activities, making it a valuable compound in biochemical research. Staurosporine appears as a white solid and is highly soluble in dimethyl sulfoxide (DMSO). Its structure includes a complex tetracyclic ring system and nitrogen-containing functionalities, contributing to its biological activity.

What are the main uses of Staurosporine (CAS: 62996-74-1)?

Staurosporine is primarily used in pharmaceutical research as a kinase inhibitor, aiding in the study of cell signaling pathways and apoptosis. It serves as a tool for drug development and is also employed in biochemical assays to investigate enzyme inhibition mechanisms. Due to its broad-spectrum activity, Staurosporine is utilized in cancer research and as a model compound for understanding kinase-dependent processes in cellular biology.

Is Staurosporine (CAS: 62996-74-1) safe?

Staurosporine is toxic and requires careful handling. It can cause harm if inhaled, ingested, or absorbed through the skin, so protective measures such as gloves, goggles, and proper ventilation are essential. Safety standards emphasize adherence to OSHA guidelines and the use of personal protective equipment (PPE). Always consult safety data sheets (SDS) for detailed handling protocols and exposure limits.

How should Staurosporine (CAS: 62996-74-1) be stored?

Staurosporine should be stored in a sealed, airtight container in a cool (2-8°C), dry, and dark location to maintain stability. It is sensitive to moisture and light, which can degrade its potency. Avoid exposure to humidity and ensure storage conditions prevent contamination. Keep away from incompatible substances and store in a well-ventilated area as per safety recommendations.