5-Nitro-1,3-benzodioxole(CAS: 2620-44-2)

5-Nitro-1,3-benzodioxole (CAS: 2620-44-2) is a white crystalline solid with a molecular weight of approximately 194.08 g/mol. It has low water solubility but is soluble in organic solvents such as ethanol and acetone. This compound is known for its high reactivity, especially towards nucleophilic substitution reactions.

5-Nitro-1,3-benzodioxole is typically synthesized via nitration of 1,3-benzodioxole. The process involves treating 1,3-benzodioxole with a nitric acid/sulfuric acid mixture at low temperature. The reaction is typically carried out in a fume hood to minimize exposure and ensure safety. The yield and selectivity can be improved by careful control of reaction conditions.

5-Nitro-1,3-benzodioxole finds applications in the pharmaceutical industry for the synthesis of certain drugs due to its structural features. It is also used in the production of dyes and pigments, as well as in the development of sensors and semiconductors. Its ability to form stable nitro groups makes it particularly useful in these applications.

When handling 5-Nitro-1,3-benzodioxole (CAS: 2620-44-2), it is crucial to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be stored in a cool, dry place away from heat sources and oxidizers. In the event of a spill, it is important to clean it up immediately using appropriate chemical spill control measures and consult the safety data sheet (SDS) for detailed instructions.