2-{(2R,6S)-6-[(2S)-2-Hydroxy-2-phenylethyl]-1-methyl-2-piperidinyl}-1-phenylethanone hydrochloride (1:1)(CAS: 134-63-4)

2-{(2R,6S)-6-[(2S)-2-Hydroxy-2-phenylethyl]-1-methyl-2-piperidinyl}-1-phenylethanone hydrochloride is a white to off-white crystalline solid. Its molecular weight is approximately 453.5 g/mol. It has a moderate solubility in water and organic solvents. This compound is known for its reactivity towards nucleophiles and its stability under acidic conditions. It can be used in various applications due to its unique chemical properties.

2-{(2R,6S)-6-[(2S)-2-Hydroxy-2-phenylethyl]-1-methyl-2-piperidinyl}-1-phenylethanone hydrochloride can be synthesized through a multi-step process involving the condensation of a substituted piperidine derivative with a phenylethanol derivative under acidic conditions. The synthesis typically involves careful control of temperature and pH to ensure high yield and selectivity. Commonly used catalysts include acids such as acetic acid or trifluoroacetic acid.

2-{(2R,6S)-6-[(2S)-2-Hydroxy-2-phenylethyl]-1-methyl-2-piperidinyl}-1-phenylethanone hydrochloride is primarily used in the pharmaceutical industry for its potential as an intermediate in the synthesis of active pharmaceutical ingredients. It can also be applied in the development of various polymers and sensors due to its unique chemical properties. Limited use is also observed in the semiconductor industry for specific applications.

When handling 2-{(2R,6S)-6-[(2S)-2-Hydroxy-2-phenylethyl]-1-methyl-2-piperidinyl}-1-phenylethanone hydrochloride, it is crucial to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure. In the event of a spill, use appropriate spill cleanup materials and dispose of according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.