Disodium 2'-deoxy-5'-O-phosphonatoadenosine(CAS: 2922-74-9)

Disodium 2'-deoxy-5'-O-phosphonatoadenosine (CAS: 2922-74-9) is a crystalline compound with a molecular weight of approximately 467.16 g/mol. It has a solubility of about 0.1 mg/mL in water. This compound is generally stable under normal conditions but can be susceptible to hydrolysis under basic or acidic conditions. It is reactive towards nucleophilic substitution at the phosphonate group.

Disodium 2'-deoxy-5'-O-phosphonatoadenosine (CAS: 2922-74-9) is typically synthesized via the phosphoramidite route, where 2'-deoxy-5'-O-phosphonatoadenosine is reacted with sodium hydroxide in an aqueous solution. This method ensures high selectivity and yield, with the use of sodium hydroxide as a catalyst. The reaction is performed under mild conditions and under an inert atmosphere to prevent decomposition.

Disodium 2'-deoxy-5'-O-phosphonatoadenosine (CAS: 2922-74-9) is primarily used in the pharmaceutical industry for the synthesis of nucleoside analogs. It is also utilized in the polymer industry for the development of nucleic acid-based polymers. Additionally, it finds applications in the development of biosensors and as a building block for semiconductor materials due to its unique chemical properties.

When handling Disodium 2'-deoxy-5'-O-phosphonatoadenosine (CAS: 2922-74-9), it is essential to use appropriate personal protective equipment (PPE) such as gloves, lab coat, and safety goggles. The substance should be handled in a fume hood to minimize inhalation risks. Spills should be cleaned up using appropriate absorbent materials and disposed of according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed handling and emergency procedures.