1-Fluoro-2-methoxy-4-nitrobenzene(CAS: 454-16-0)

1-Fluoro-2-methoxy-4-nitrobenzene has a crystalline form and a molecular weight of 225.06 g/mol. It is slightly soluble in water but miscible with organic solvents. This compound is known for its reactivity, particularly in nucleophilic substitution and reduction reactions.

1-Fluoro-2-methoxy-4-nitrobenzene is commonly synthesized via the nitration of 2-methoxybenzene followed by fluorination. The process involves the use of nitric acid and sulfuric acid as reagents for nitration, and hydrogen fluoride for fluorination. The yield is typically around 70-80%.

1-Fluoro-2-methoxy-4-nitrobenzene is primarily used in the pharmaceutical industry for the synthesis of intermediate compounds. It also finds applications in the development of sensors and certain polymers due to its functional groups and reactivity.

Handling 1-Fluoro-2-methoxy-4-nitrobenzene requires the use of personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a fume hood to minimize exposure. Spills should be handled with appropriate absorbents and the area should be cleaned thoroughly. Always refer to the Safety Data Sheet (SDS) for detailed emergency procedures.