Compound Q&A

How is 1-Fluoro-2-methoxy-4-nitrobenzene (CAS: 454-16-0) typically synthesized?

Answer

1-Fluoro-2-methoxy-4-nitrobenzene
1-Fluoro-2-methoxy-4-nitrobenzene is commonly synthesized via the nitration of 2-methoxybenzene followed by fluorination. The process involves the use of nitric acid and sulfuric acid as reagents for nitration, and hydrogen fluoride for fluorination. The yield is typically around 70-80%.

About

CAS No 454-16-0
English Name 1-Fluoro-2-methoxy-4-nitrobenzene
Molecular Formula C7H6FNO3
Molecular Weight 171.13 g/mol
SMILES COC1=C(C=CC(=C1)[N+](=O)[O-])F
InChIKey AZNKKZHZGDZSIF-UHFFFAOYSA-N
Last Updated: 2025-10-13 17:50

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