trans-4-(2-Methyl-2-propanyl)cyclohexanol(CAS: 21862-63-5)

trans-4-(2-Methyl-2-propanyl)cyclohexanol is a colorless to light yellow liquid with a molecular weight of approximately 154.26 g/mol. It has a high boiling point of around 220°C and a low solubility in water (less than 1 g/L). This compound is moderately reactive, particularly towards bases and oxidizing agents. It is often used in organic synthesis and as a precursor in various chemical processes.

trans-4-(2-Methyl-2-propanyl)cyclohexanol is typically synthesized through a Wittig reaction or a modified Robinson annulation. The Wittig reaction involves the reaction of phenylphosphonium bromide with cyclohexanone in the presence of a Lewis acid catalyst. The modified Robinson annulation involves the condensation of cyclohexanone with 2-methyl-2-propanol followed by base catalyzed cyclization.

trans-4-(2-Methyl-2-propanyl)cyclohexanol is used in the pharmaceutical industry for the synthesis of drug intermediates. It is also utilized in the polymer industry, particularly in the modification of polymers to enhance their mechanical properties. Additionally, it is employed in the sensor and semiconductor industries for various applications, including the production of gas sensors and electronic devices.

When handling trans-4-(2-Methyl-2-propanyl)cyclohexanol, it is essential to use appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. Handle the compound in a well-ventilated area or a fume hood to minimize exposure. Spills should be cleaned up using appropriate absorbents, and the area should be well-ventilated. Always consult the Material Safety Data Sheet (MSDS) for detailed safety information and emergency procedures.