5-Chloro-6-isoquinolinol(CAS: 918488-41-2)

5-Chloro-6-isoquinolinol (CAS: 918488-41-2) is a crystalline solid with a molecular weight of approximately 192.57 g/mol. It is slightly soluble in water and soluble in common organic solvents like ethanol and acetone. This compound is known for its moderate reactivity, especially towards nucleophilic substitution reactions. It can be a key intermediate in various organic syntheses and has potential use in pharmaceutical applications.

5-Chloro-6-isoquinolinol (CAS: 918488-41-2) is commonly synthesized via the chlorination of 6-isoquinoline carboxylic acid with thionyl chloride followed by base treatment. This method provides a yield of around 85%, with high selectivity towards the chlorination at the desired position. Other methods include direct chlorination of isoquinoline derivatives under specific conditions.

5-Chloro-6-isoquinolinol (CAS: 918488-41-2) is primarily used in the pharmaceutical industry as an intermediate in drug synthesis. It also finds applications in the chemical sensors and semiconductors industry due to its unique electronic properties. Its suitability as a precursor in polymer chemistry is also being explored.

When handling 5-Chloro-6-isoquinolinol (CAS: 918488-41-2), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be carried out in a well-ventilated fume hood to minimize exposure. In case of a spill, neutralize any strong acids or bases present before cleaning up. Always consult the Material Safety Data Sheet (MSDS) for detailed safety guidelines and emergency procedures.