7-Nitro-2H-indazole(CAS: 2942-42-9)

7-Nitro-2H-indazole (CAS: 2942-42-9) is a yellow solid with a crystalline form. Its molecular weight is approximately 167.11 g/mol. It has a solubility of 1.5 mg/mL in water and is practically insoluble in organic solvents like ethanol and acetone. Chemically, it is relatively stable but can undergo nitration and reduction reactions. It is soluble in common organic solvents such as dichloromethane and acetonitrile.

7-Nitro-2H-indazole is typically synthesized by nitration of 2H-indazole with concentrated nitric acid in the presence of a catalyst like sulfuric acid. The process requires careful temperature control to achieve high yield and selectivity. The overall yield is around 70-80%, and the reaction is exothermic, necessitating cooling to prevent decomposition.

7-Nitro-2H-indazole is primarily used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. It also finds applications in the polymer industry for the development of functional polymers, in the semiconductor industry for organic electronic devices, and in the sensor industry for the fabrication of gas sensors.

When handling 7-Nitro-2H-indazole (CAS: 2942-42-9), it is crucial to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. The compound should be handled in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be immediately cleaned up with appropriate absorbent materials and disposed of according to local regulations. Always consult the Safety Data Sheet (SDS) for specific handling and disposal instructions.