5-Iodo-3H-pyrrolo[2,3-D]pyrimidin-4(7H)-one(CAS: 135352-71-5)

5-Iodo-3H-pyrrolo[2,3-D]pyrimidin-4(7H)-one is a crystalline solid with a molecular weight of approximately 263.04 g/mol. It has a low solubility in water but is more soluble in polar organic solvents like acetonitrile. The compound is moderately reactive, particularly towards nucleophiles, and exhibits good stability under normal conditions.

5-Iodo-3H-pyrrolo[2,3-D]pyrimidin-4(7H)-one is commonly synthesized through the iodination of 3H-pyrrolo[2,3-D]pyrimidin-4(7H)-one using sodium iodide in the presence of an appropriate base such as sodium hydride. The reaction yields the desired product in good to excellent purity and selectivity.

5-Iodo-3H-pyrrolo[2,3-D]pyrimidin-4(7H)-one is used in the pharmaceutical industry for the development of certain drug candidates, particularly in the area of antiviral and antitumor agents. It also has potential applications in the chemical industry for the synthesis of other organic compounds.

When handling 5-Iodo-3H-pyrrolo[2,3-D]pyrimidin-4(7H)-one, it is essential to use appropriate personal protective equipment (PPE) such as gloves and safety goggles to protect against skin and eye contact. The compound should be stored in a dry, cool place, away from sources of heat and ignition. Spills should be cleaned up carefully, following the safety data sheet (SDS) guidelines, and the area should be well-ventilated.