Ethyl 5-amino-4-cyano-1-(4-fluorophenyl)-1H-pyrazole-3-carboxylate(CAS: 1001665-65-1)

Ethyl 5-amino-4-cyano-1-(4-fluorophenyl)-1H-pyrazole-3-carboxylate (CAS: 1001665-65-1) is a crystalline solid with a molecular weight of approximately 326.24 g/mol. It has limited water solubility and is soluble in organic solvents like DMSO and DMF. This compound is known for its reactivity, particularly in nucleophilic substitution reactions. It can form stable salts and esters.

Ethyl 5-amino-4-cyano-1-(4-fluorophenyl)-1H-pyrazole-3-carboxylate (CAS: 1001665-65-1) is typically synthesized via a multistep procedure involving the reaction of 4-fluorophenyl isocyanate with ethyl cyanoacetate followed by condensation with 1-amino-3-cyano-5-methylpyrazole. The reaction yields the desired compound with good selectivity and moderate to high yield depending on the conditions.

Ethyl 5-amino-4-cyano-1-(4-fluorophenyl)-1H-pyrazole-3-carboxylate (CAS: 1001665-65-1) is primarily used in the pharmaceutical industry for the synthesis of various medicinal compounds. It may also have applications in the polymer industry for developing specific materials, and in sensor technology for its chemical reactivity.

When handling Ethyl 5-amino-4-cyano-1-(4-fluorophenyl)-1H-pyrazole-3-carboxylate (CAS: 1001665-65-1), it is essential to wear personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or fume hood to minimize exposure. Spills should be cleaned up immediately with appropriate absorbents, and the area should be properly decontaminated. Always consult the Safety Data Sheet (SDS) for specific handling and disposal instructions.