Boc-L-His(Bom)-OH(CAS: 79950-65-5)

Boc-L-His(Bom)-OH is a white to off-white powder with a crystalline form. It has a molecular weight of approximately 432.44 Da. Soluble in water and organic solvents like DMF, it is less reactive in general but can undergo esterification and peptide coupling reactions. Its solubility is 36 mg/mL in water at 25°C and 50 mg/mL in DMF.

Boc-L-His(Bom)-OH is synthesized via solid-phase synthesis, which involves coupling L-His(Bom) to a Boc-protected amino acid. The synthesis typically uses HATU or DCM as a coupling reagent, with a yield of about 70-80%. The process is selective and yields a high-quality product suitable for further peptide synthesis.

Boc-L-His(Bom)-OH is widely used in the pharmaceutical industry for the synthesis of peptide-based drugs. It is also utilized in the polymer industry for modifying and functionalizing polymers. Additionally, it plays a role in the development of biosensors and in semiconductor technology due to its unique chemical properties.

When handling Boc-L-His(Bom)-OH, it is essential to wear appropriate personal protective equipment (PPE), including gloves, goggles, and lab coat. Work in a well-ventilated area or fume hood to minimize exposure. Spills should be cleaned up immediately using a suitable absorbent material. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.