Zebularine(CAS: 3690-10-6)

Zebularine is a white crystalline powder with a molecular weight of approximately 285.25 g/mol. It is poorly soluble in water but soluble in organic solvents such as methanol and ethanol. Chemically, it exhibits mild reactivity, especially under basic conditions. Zebularine is stable under standard storage conditions and requires minimal handling precautions.

Zebularine is typically synthesized through a multistep process involving the condensation of 4'-deoxy-4'-aza-2'-deoxyadenosine with 2'-deoxyadenosine-5'-monophosphate. The synthesis involves the use of common organic solvents and catalysts such as acetic anhydride and sodium hydride, yielding a product with a high degree of selectivity and a yield of around 70-80%.

Zebularine is primarily used in the pharmaceutical industry for its potential as an inhibitor of DNA methyltransferases. It has also found applications in research for gene regulation studies. Additionally, it is used in some biosensors and as a tool compound in academic research.

When handling Zebularine, ensure proper personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or a fume hood. Store it at room temperature away from direct sunlight and heat sources. In case of spill, use appropriate cleanup materials and follow standard laboratory procedures. Refer to the Safety Data Sheet (SDS) for detailed handling instructions.