2-Amino-3-(trifluoromethoxy)benzoic acid(CAS: 561304-41-4)

2-Amino-3-(trifluoromethoxy)benzoic acid (CAS: 561304-41-4) is a crystalline compound with a molecular weight of approximately 264.12 g/mol. It has a high solubility in water (10 g/L at 20°C) and poor solubility in common organic solvents. It is moderately reactive, forming stable complexes with metal ions and showing some basic and acidic properties.

2-Amino-3-(trifluoromethoxy)benzoic acid is typically synthesized via the Friedel-Crafts amination of 3-(trifluoromethoxy)benzoic acid with an aromatic amine. The reaction is catalyzed by a Lewis acid like aluminum trichloride. The overall yield is moderate, around 60-70%, with good selectivity towards the target product.

2-Amino-3-(trifluoromethoxy)benzoic acid finds applications in the pharmaceutical industry, particularly in the synthesis of various drug compounds. It is also used in the development of sensors and semiconductors due to its unique electronic properties. Additionally, it has potential uses in the polymer industry for specific functional polymer modification.

When handling 2-Amino-3-(trifluoromethoxy)benzoic acid (CAS: 561304-41-4), safety precautions include wearing appropriate personal protective equipment (PPE) such as gloves and goggles. Work in a fume hood to minimize exposure to vapors. Spills should be cleaned up with absorbent materials and disposed of according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed handling and safety information.