1-[(4-Methylphenyl)sulfonyl]-1H-pyrrole-3-carboxylic acid(CAS: 106058-86-0)

1-[(4-Methylphenyl)sulfonyl]-1H-pyrrole-3-carboxylic acid is a white to off-white crystalline solid with a molecular weight of approximately 315.27 g/mol. It has low aqueous solubility and good solubility in polar organic solvents. The compound is relatively stable under normal conditions but may react with strong bases. It is used in various applications requiring its unique chemical properties.

1-[(4-Methylphenyl)sulfonyl]-1H-pyrrole-3-carboxylic acid is usually synthesized via a multi-step process involving the protection of a pyrrole ring, followed by sulfonylation and carboxylation. Key steps include the use of sulfonyl chlorides and carboxylic acids, with the reaction typically carried out in anhydrous conditions and under appropriate catalysts to ensure high yield and selectivity.

1-[(4-Methylphenyl)sulfonyl]-1H-pyrrole-3-carboxylic acid finds applications in pharmaceuticals, where it serves as a precursor for drug synthesis. It is also used in the polymer industry for modifying polymer properties and in the semiconductor industry for creating specific functional groups required in device fabrication. Additionally, it is utilized in the development of sensors and other chemical reagents.

When handling 1-[(4-Methylphenyl)sulfonyl]-1H-pyrrole-3-carboxylic acid, it is essential to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Ensure adequate ventilation by working in a fume hood and avoid skin contact and inhalation of dust. In case of spillage, clean up using appropriate absorbents and dispose of waste in accordance with local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and emergency procedures.