N-[(8S)-4-Amino-6-methyl-5-(3-quinolinyl)-8,9-dihydropyrimido[5,4-b]indolizin-8-yl]acrylamide(CAS: 1661854-97-2)

The compound is a crystalline solid with a high molecular weight around 600 g/mol. It has good solubility in common organic solvents like DMSO and moderate solubility in water. Chemically, it is reactive towards nucleophiles and can undergo various transformations such as amidation and conjugate addition. It is stable under normal laboratory conditions but should be stored away from strong acids and bases.

This compound is typically synthesized through a multistep procedure involving the reaction of 3-quinolinecarboxaldehyde with N-methyl-2-aminoacrylamide under acidic conditions. Amination and coupling reactions are key steps, with high selectivity and good yields. Commonly used catalysts include palladium(II) acetate and triphenylphosphine.

This compound is primarily used in the pharmaceutical industry for its potential as an intermediate in the development of novel drugs. It may also find applications in polymer chemistry for the synthesis of functional materials and in sensor technology for its ability to detect specific analytes.

When handling this compound, safety goggles and gloves must be worn to prevent skin contact and eye irritation. It should be stored in a fume hood due to its potential volatility. In case of a spill, it should be carefully cleaned up with caution to avoid inhaling the powder. Always refer to the SDS for detailed safety information and follow lab safety protocols.