Compound Q&A
How is N-[(8S)-4-Amino-6-methyl-5-(3-quinolinyl)-8,9-dihydropyrimido[5,4-b]indolizin-8-yl]acrylamide (CAS: 1661854-97-2) typically synthesized?
Answer
![N-[(8S)-4-Amino-6-methyl-5-(3-quinolinyl)-8,9-dihydropyrimido[5,4-b]indolizin-8-yl]acrylamide](https://static.chemtradehub.com/structs/166/1661854-97-2-d5a7.webp "N-[(8S)-4-Amino-6-methyl-5-(3-quinolinyl)-8,9-dihydropyrimido[5,4-b]indolizin-8-yl]acrylamide")
This compound is typically synthesized through a multistep procedure involving the reaction of 3-quinolinecarboxaldehyde with N-methyl-2-aminoacrylamide under acidic conditions. Amination and coupling reactions are key steps, with high selectivity and good yields. Commonly used catalysts include palladium(II) acetate and triphenylphosphine.
About
CAS No
1661854-97-2
English Name
N-[(8S)-4-Amino-6-methyl-5-(3-quinolinyl)-8,9-dihydropyrimido[5,4-b]indolizin-8-yl]acrylamide
Molecular Formula
C23H20N6O
Molecular Weight
396.45 g/mol
SMILES
CC1=C[C@@H](Cn2c1c(c3c2ncnc3N)c4cc5ccccc5nc4)NC(=O)C=C
InChIKey
MKCYPWYURWOKST-INIZCTEOSA-N
Last Updated: 2025-10-22 12:37
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