Ethyl (4-nitrophenyl)acetate(CAS: 5445-26-1)

Ethyl (4-nitrophenyl)acetate (CAS: 5445-26-1) is a crystalline solid with a molecular weight of approximately 228.13 g/mol. It has a high solubility in organic solvents like ethanol and acetone but is sparingly soluble in water. Chemically, it is a nitrophenyl ester and exhibits moderate reactivity, particularly in nucleophilic substitution reactions. It is used in various applications requiring specific functional groups for synthesis and derivatization.

Ethyl (4-nitrophenyl)acetate (CAS: 5445-26-1) is typically synthesized by the esterification of 4-nitrophenol with acetic anhydride in the presence of a strong acid catalyst like sulfuric acid. The reaction is carried out at elevated temperatures to achieve high yield and selectivity. This compound can also be prepared by other methods, such as direct nitration of ethyl phenylacetate, followed by purification.

Ethyl (4-nitrophenyl)acetate (CAS: 5445-26-1) is primarily used in the pharmaceutical industry for the synthesis of various drugs and intermediates. It is also utilized in the production of organic pigments, dyes, and other chemical intermediates. Additionally, this compound has applications in the research and development of new materials, such as polymers and semiconductors.

When handling Ethyl (4-nitrophenyl)acetate (CAS: 5445-26-1), it is crucial to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. This compound can irritate the skin and eyes, and fume hoods should be used to minimize inhalation risks. In the event of a spill, it should be handled carefully, and the area should be well-ventilated. Always refer to the Safety Data Sheet (SDS) for detailed emergency procedures and storage information.