2-(4-Butylphenyl)propanoic acid(CAS: 3585-49-7)

2-(4-Butylphenyl)propanoic acid is a crystalline solid with a molecular weight of approximately 214.35 g/mol. It is slightly soluble in water and soluble in organic solvents like ethanol and acetone. The compound is reactive towards bases and can participate in esterification reactions. It is not flammable but appropriate handling precautions should be taken to avoid skin and eye contact.

2-(4-Butylphenyl)propanoic acid is commonly synthesized via a Friedel-Crafts acylation process, where 4-butylation of phenylacetic acid is followed by acylation with acetyl chloride. The reaction typically requires a Lewis acid catalyst like aluminum chloride and is conducted under anhydrous conditions to achieve a yield of around 70-80%.

2-(4-Butylphenyl)propanoic acid finds applications in pharmaceuticals, where it serves as a precursor for certain drug molecules. It is also used in the production of sensors for environmental monitoring and in the synthesis of specific polymers that require specific functional groups. Its use in semiconductors is limited but it can be a component in some organic semiconductor materials.

When handling 2-(4-Butylphenyl)propanoic acid, it is important to wear appropriate personal protective equipment (PPE), including safety goggles, gloves, and a lab coat. Ensure the use of a fume hood to minimize inhalation risk. Spills should be cleaned up using absorbent materials and disposed of according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed handling and safety information.