4-{[(Benzyloxy)carbonyl]amino}benzoic acid(CAS: 5330-71-2)

4-{[(Benzyloxy)carbonyl]amino}benzoic acid is a white crystalline solid with a molecular weight of approximately 330.28 g/mol. It has a pKa of around 4.6 and is sparingly soluble in water. The compound is prone to hydrolysis under basic conditions and exhibits moderate reactivity in organic synthesis.

4-{[(Benzyloxy)carbonyl]amino}benzoic acid can be synthesized via the coupling of benzyloxycarbonyl chloride with aniline followed by condensation with benzoic acid. The reaction is typically performed in an organic solvent such as dichloromethane or acetonitrile with a suitable base like triethylamine. The yield is generally around 85-90%.

4-{[(Benzyloxy)carbonyl]amino}benzoic acid is primarily used in the pharmaceutical and chemical industry for the synthesis of various drug intermediates and in some cases as a building block for organic synthesis. It is also utilized in the production of certain polymers and as a reagent in analytical chemistry.

When handling 4-{[(Benzyloxy)carbonyl]amino}benzoic acid, it is important to wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. The substance should be handled in a fume hood to minimize exposure to vapors. In case of a spill, it should be neutralized with an appropriate base and disposed of according to local regulations. Always refer to the safety data sheet (SDS) for specific handling instructions.