2-Bromo-5-nitrobenzene-1-sulfonyl chloride(CAS: 98130-55-3)

2-Bromo-5-nitrobenzene-1-sulfonyl chloride is a crystalline compound with a molecular weight of approximately 293.04 g/mol. It has a high solubility in organic solvents like dichloromethane and acetone. Chemically, it is highly reactive, particularly with nucleophiles, and exhibits strong electrophilic aromatic substitution reactivity.

2-Bromo-5-nitrobenzene-1-sulfonyl chloride is synthesized via the reaction of 5-nitrobenzenesulfonic acid with bromine in the presence of a base like sodium hydroxide. The reaction is conducted in an inert solvent to prevent unwanted side reactions. The product is isolated by extraction and recrystallization.

2-Bromo-5-nitrobenzene-1-sulfonyl chloride finds application in pharmaceuticals, particularly in the synthesis of medicinal compounds. It is also used in the preparation of organic dyes and in polymer chemistry for developing functional materials. Additionally, it is utilized in the development of sensors and semiconductors.

When handling 2-Bromo-5-nitrobenzene-1-sulfonyl chloride, always wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or a fume hood to avoid inhalation. Spills should be absorbed with an inert material and disposed of according to local regulations. Refer to the safety data sheet (SDS) for detailed handling instructions.